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KMID : 0861420100140020155
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Korean Journal of Nuclear Medicine Technology
2010 Volume.14 No. 2 p.155 ~ p.158
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Usefulness of Hepatocellular Carcinoma by Hepatic Arterial Perfusion Scintigraphy with 99mTc-MAA
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Jung Ji-Wook
Lee Hyo-Yeong
Yun Jong-Jun
Lee Hwa-Jin
Lee Mu-Seok
Song Hyeon-Seok
Park Se-Yun
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Abstract
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Purpose: 99mTc-macroaggregated albumin (MAA) hepatic arterial perfusion scintigraphy was known for useful
method to evaluate patients receiving intraarterial chemotherapy for liver cancer. This study evaluate about
usefulness of normal liver on hepatocellular carcinoma (HCC) from HCC patients. This study is to see the
usefullness of Hepatic Arterial Perfusion Scintigraphy (HAPS) by measuring mass size, shape, lung shunting
and tumor to normal ratio (T/N ratio) in relative blood stream of HCC patients compared with HCC on normal
liver.
Materials and Methods: From June 2009 to September 2009, HAPS studies were performed on 7 patients (men 6, women 1, mean 64) who were diagnosed HCC. HAPS was performed after proper hepatic artery 99mTc-MAA of 5 mCi (185 MBq) injection by catheter. We performed anterior, posterior, both lateral view, SPECT of chest and abdomen. Then we set up ROI and calculated lung shunting, T/N ratio for each count, count/pixel (mean value).
Results: Tumor and liver size analyzed by ROI of anterior, posterior view are 2.0-10.8 cm (mean 3.75 cm), 8.8-18.5 cm (mean 14.6 cm). T/N ratio analyzed by total tumor and total normal mean value are 2.41-5.76 (mean 3.8). lung shunting analyzed by total liver count is 3.14-13.92% (mean 6.77%).
Conclusion: HAPS with 99mTc-MAA can evaluate mass si ze, location, quantitative analysis through T/N ratio. also HAPS can evaluate detection of arteriovenous shunt through lung uptake before radioisotope therapy.Therefore HAPS with 99mTc-MAA can be useful method in aspect of evaluation and treatment of HCC.
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KEYWORD
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99mTc-MAA, HAPS, Lung shunting, T/N ratio
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